Group Introduction

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           Peking University Biomedical Informatics Department Li-Tingting Group belongs to PKU school of Basic Medical Sciences. Our group dedicates in computational analysis on bimolecular condensates, regulatory networks of protein post-translational modification and integrative mining of various high-throughput data. The mission of us is to pursue excellence in scientific research and education on fundamental questions in life science with informatics and systems approaches, and on the informatics mechanism of life system. Our laboratory locates in PKU Health Science Center campus.
           Liquid-liquid phase separation (LLPS) is an important mechanism that mediates the compartmentalization of proteins and nucleic acids in cells, and it has been proven to regulate various biological functions. Our lab tries to explore this process via the combination of experiments and bioinformatics tools.

     Tutor's Introduction

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           Li Tingting, Boya Distinguished Professor and Tenured Full Professor at the School of Basic Medical Sciences, Peking University Health Science Center. Our lab focuses on phase separation and transition within biological context. We developed a series of databases and prediction tools & methods fusing multiple bioinformation and explores potential drug target from phase separation perspective.
           Doctor Li was the sub-project leader of the National Key Research and Development Program of China, leading 4 projects funded by the National Natural Science Foundation and participating 3 projects of National Key Research & Development Program as backbone investigator. She also serves as a member of Bioinformatics and Artificial Life Committee of Chinese Association of Artificial Intelligence, member of Computational Biology and Bioinformatics Committee of Chinese Society of Biotechnology, member of Bioinformatics Committee of China Computer Federation and council member of the 1st Biomolecular Phase Separation & Transition Committee of Biophysical Society of China.

     Group Research Interest

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           1. Composition and dynamic regulation of bimolecular condensatess

           2. Computational analysis on phase separation and phase transition

           3. Abnormal phase separation and diseases

           4. Regulatory networks of protein post-translational modification

           5. Integrative mining of mass spectrum data, next-generation sequencing data and other omics data